The run line is baseball's version of the point spread. The favorite is typically -1.5 runs, meaning they must win by 2 or more runs. The underdog is +1.5, meaning they can lose by 1 run and still cover. Run line odds adjust based on each team's likelihood of covering.

Moneyline betting is the most popular way to bet on MLB. You simply pick which team will win the game. Unlike football and basketball, there's no point spread involved. Favorites have negative odds (e.g., -150) and underdogs have positive odds (e.g., +130).

Totals betting involves predicting whether the combined score of both teams will be over or under a set number. MLB totals typically range from 7-10 runs depending on the pitching matchup, ballpark, and weather conditions.