NFL Odds

Live NFL betting lines for October 22, 2026, compared across sportsbooks. The best price on each side is highlighted.

Reading NFL odds

We show American odds throughout. A negative number is the favourite and tells you the stake needed to win $100; a positive number is the underdog and tells you the profit on a $100 stake. Shopping for the best number matters more than most bettors assume — the difference between -110 and -105 on every bet is the difference between a losing and a break-even season.

On each match page we also publish the hold: the margin the bookmaker has built into that market. Use our hold calculator to check any market yourself, and the odds calculator to convert formats and work out returns.